We noticed that the depletion of RAB5A in tumor cells reduced the staining of M2-macrophage marker CD163, as well as the pan-macrophage marker CD68, in mouse xenograft, this alteration of both macrophage and M2-macrophage might be attributed to the less transformation of M1 to M2 macrophage and the reduced infiltration of macrophage, which deserved further investigation. Here, CD163 is linked to neoplasm.