Figure 2 shows the most distinct signaling pathways between NAM and AM, including the S100 protein family signaling pathway, wound healing signaling pathway, phagosome formation pathway, stearate biosynthesis I pathway, focal adhesion kinase (FAK) signaling pathway, epithelial mesenchymal transition (EMT) regulation signaling pathway, cAMP‐response element‐binding protein (CREB) signaling pathway, tumor microenvironment signaling pathway, and natural killer cell signaling pathway. This evidence concerns the gene CREB1 and neoplasm.