Through IPA analysis, we identified the following pathways as the most significantly different regulatory pathways between NAM and AM: S100 protein family signaling pathway, wound healing signaling pathway, phagosome formation pathway, stearate biosynthesis I pathway, FAK signaling pathway, EMT regulation signaling pathway, CREB signaling pathway, tumor microenvironment signaling pathway, natural killer cell signaling pathway, aldosterone signaling pathway, and interleukin 8 (IL‐8) signaling pathway. The gene discussed is CREB1; the disease is neoplasm.