MAPT and tauopathy: As approximately 60-80% of C. elegans genes have an analogous human counterpart and about 42% of human disease genes have a C. elegans ortholog (Markaki and Tavernarakis, 2010), genetic targeting of tauopathy disease mechanisms in Dendra2::tau C. elegans could shed light on how those mechanisms affect tau proteostasis and could be translatable to mammalian models.