MAPT and tauopathy: In primary tauopathies such as frontotemporal lobar degeneration, Pick's disease, corticobasal degeneration and progressive supranuclear palsy, mutations in MAPT cause changes in expressed tau splice isoforms, post-translational modifications, microtubule affinity, folding or aggregation propensity, which likely lead to the various pathological tau structures and localization observed in these diseases (Naseri et al., 2019; Strang et al., 2019; Gallo et al., 2022).