We also show that TDP-43 expression exacerbated motor impairment of single-copy Dendra2::tau-expressing animals at days 1 and 5 of adulthood (Fig. S2C,D), demonstrating the utility of the single-copy Dendra2::tau model in detecting tauopathy phenotype exacerbation. The gene discussed is TARDBP; the disease is tauopathy.