Although we had expected TDP-43 to impair Dendra2::tau turnover as TDP-43 dysregulates proteostatic pathways (Leibiger et al., 2018; Ormeño et al., 2020; Yin et al., 2021), our results suggest that TDP-43 does not stabilize Dendra2::tau but instead promotes its accumulation, possibly through enhanced protein synthesis to enhance tauopathy phenotype. Here, TARDBP is linked to tauopathy.