These pathways have been consistently associated with ALS/FTD (Serpente et al., 2015; Granatiero et al., 2021; Kallstig et al., 2021; Chua et al., 2022; Ohshiro et al., 2022), and C9orf72-ALS/FTD specifically (Serpente et al., 2015; Shao et al., 2020; Beckers et al., 2021). The gene discussed is C9orf72; the disease is frontotemporal dementia.