Atrophy in striatum, including caudate and nucleus accumbens, is another key feature in the ALS/FTD patients with behavioral and cognitive abnormalities, with and without C9orf72 mutations (Masuda et al., 2016; Mirzaeva et al., 2016; Sobue et al., 2018). The gene discussed is C9orf72; the disease is frontotemporal dementia.