Also, within layer 5b of anterior cingulate and frontoinsular cortices in brain tissue of FTD patients, VEN and fork cells show disproportionate tau aggregation in FTLD-tau (Lin et al., 2019) and TDP-43 aggregation in FTLD-TDP (Nana et al., 2019; Vatsavayai et al., 2019), suggesting that VEN and fork cell biology are key aspects of FTD pathobiology. Here, MAPT is linked to frontotemporal dementia.