To do this, we used the publicly available Cell-type Specific Expression Analysis (CSEA) tools, which extracts data from the Brainspan database.6 These genes were enriched for several cell types or systems previously implicated in ALS and FTD (Figure 6) (BH adjusted p-value < 0.05), including layer 5b cells (Genc et al., 2017; Nana et al., 2019; Vatsavayai et al., 2019), cholinergic motor neurons in the spinal cord and brainstem (Casas et al., 2013), and dopamine type 1 and 2 receptor-positive (Drd1 + , Drd2 +) medium spiny neurons of striatum (Riku et al., 2016; Sobue et al., 2018). This evidence concerns the gene DRD1 and amyotrophic lateral sclerosis.