Therefore, to strengthen the connection between correlated gene expression and potential pathogenic roles, we explore whether genes associated with specific neurodegenerative diseases, such as SMCR8 and WDR41, known to form a complex with C9orf72 as part of normal cellular physiology, and TREM2, TYROBP, and GRN associated with leukoencephalopathy and FTD, show correlated gene expression. The gene discussed is TYROBP; the disease is Leukoencephalopathy.