Therefore, to strengthen the connection between correlated gene expression and potential pathogenic roles, we explore whether genes associated with specific neurodegenerative diseases, such as SMCR8 and WDR41, known to form a complex with C9orf72 as part of normal cellular physiology, and TREM2, TYROBP, and GRN associated with leukoencephalopathy and FTD, show correlated gene expression. This evidence concerns the gene C9orf72 and Leukoencephalopathy.