CD147 is a hub Ag that binds to other proteins (Intergrin, Hyaluronan, CD44, P‐gp/ABCB1, ABCG2, MCT‐1/4, CypA/B, and Gasdermin D) to drive the malignancy of cancer cells.2, 3, 5, 14, 26, 27, 28, 34. This evidence concerns the gene CD44 and cancer.