found that heparin‐binding epidermal growth factor‐like growth factor (HBEGF)+ macrophages can express NR4A3, urokinase plasminogen activator receptor, and CXCL2, promoting the inflammatory response and invasive behavior of RA‐FLS through epiregulin‐dependent cell‐cell interaction. Here, NR4A3 is linked to rheumatoid arthritis.