TNF‐α, a major proinflammatory cytokine in RA, is found to amplify inflammation through activating nuclear factor‐kappa B (NF‐κB) pathway, upregulating TNFR II, and inducing receptor activator of NF‐κB ligand (RANKL) secretion in RA‐FLS for osteoclast formation.35 This evidence concerns the gene NFKB1 and rheumatoid arthritis.