The Polycladia crinita extract mediated its promising anticancerous action by enhancing apoptosis and mitigating inflammation via VEGF, Notch 1, NF-кB, IL-6, Cyclin D1, Caspase 9 and Caspase 3 expression/level, which manifested in promoting the total survival rate and the tumor volume decrease. Here, NOTCH1 is linked to neoplasm.