SMN1 and Alzheimer disease: As whole animals, transgenic pigs harboring human disease-causing mutant genes phenotypically replicate ALS (Yang et al., 2014), Huntington’s disease (Yan et al., 2018), AD (Lee et al., 2017), SMA (Lorson et al., 2011), and ataxia telangiectasia (Beraldi et al., 2015).