It is notable that loss of HCN2 in oligodendrocytes was not associated with an overt behavioral phenotype in the absence of EAE, suggesting the therapies directed at HCN channels [as has been suggested for the treatment of Major Depressive Disorder and delirium (Han et al., 2015, 2022; Lyman et al., 2017a; Lyman, 2023)] are unlikely to cause adverse effects on oligodendrocytes. Here, HCN2 is linked to delirium.