Furthermore, the KEGG analysis demonstrated that these genes were associated with pathways such as NOD-like receptor signaling pathway, chemokine signaling pathway, TNF signaling pathway, etc. We have also identified key players involved in the development of chronic myeloid leukaemia - CDKN1A, MYC and NFKBIA. Here, TNF is linked to chronic myelogenous leukemia, BCR-ABL1 positive.