In addition, GSVA results revealed that growth hormone receptor signaling via JAK-STAT, negative regulation of autophagy, acute myeloid leukemia, cell growth, TGF beta signaling, positive regulation of inflammatory response to antigenic stimulus and P53 pathway were activated in the C2 subgroup, which were consistent with the results of KEGG and GSEA (Figures 10B, C). The gene discussed is TP53; the disease is acute myeloid leukemia.