OCA2 and cystic fibrosis: Indeed, because we used here total PBMCs and did not further purify their different components, it is in principle difficult to distinguish whether CF mononuclear cells and neutrophils are ‘per se’ intrinsically different eg in their receptor collection (explaining their differential responses to PMA/iono or P.a), or whether soluble factors might act ‘in trans’ to affect their function.