CFTR and cystic fibrosis: Cystic Fibrosis (CF) is the commonest genetically inherited disease in the population (1 in 4,500 newborns) and 70% of people with CF (pwCF) harbour the F508Del mutation, which results in misfolding and incorrect addressing of the Cl- channel CFTR to the epithelial membrane (1–3) and subsequent dysregulation of fluid homeostasis on epithelial surfaces (4).