Notably, PAO1 did not induce the ‘lymphoid signature’ cytokines mRNA (IL-17, IL-13, IL-22, and IFN-g) in CF cells (Figures 7A–D), and their fold increase was also more modest in HC cells (6.3 and 88 for IFN-g and IL-17, respectively), when compared with that induced by PMA/iono (see Figure 5 above). This evidence concerns the gene SMOX and cystic fibrosis.