Phenotypically, we showed by FACS analysis that the main difference in intra-cellular cytokine production between PMA/iono-stimulated HC and CF PBMCs resided in the Lin+ T cell population, with overall decreased cytokine inducibility in CF cells (Figure 4), except for IL-17+IL-22+ cells, even though they accounted for a very low percentage of total Lin+ cells (0.01-0.04%), overall mirroring the described Th17 phenotype in pwCF. The gene discussed is IL22; the disease is cystic fibrosis.