In our hands, the lack of HRG causes a marked lowering of macrophage infiltration in MASH-related HCCs along with a reduction in the expression of pro-inflammatory cytokines (IL-1β, IL-6, and IL-12) as well as of IL-10 and TREM2, a marker of HCC-associated macrophages (45, 46). This evidence concerns the gene HRG and hepatocellular carcinoma.