We also evidenced a significant decrease in transcript levels for IL-10, programmed death ligand 1 (PDL1), and triggering receptor expressed on myeloid cells 2 (TREM2), a surface receptor expressed by the so-called NASH-associated macrophages (NAMs) (45) as well as by HCC-associated macrophages (46) (Figure 4C). This evidence concerns the gene CD274 and metabolic dysfunction-associated steatohepatitis.