The TDCA-CM greatly facilitated tumor cell viability (Figures 6A, B), invasion (Figure 6C; Supplementary Figure 4A), and motility (Figures 6D, E; Supplementary Figure 4B) in contrast to the co-culture with the control, while HMGB1 neutralizing Abs antagonized this effect. The gene discussed is HMGB1; the disease is neoplasm.