We observed reduced Nek6 expression in peritoneal TCL1-Tg BAFF-/- CLL cells, suggesting reduced cell cycle progression and possibly explaining reduced numbers of these cells in the peritoneal cavity TCL1-Tg BAFF-/- mice compared to the same site in TCL1-Tg controls. This evidence concerns the gene NEK6 and B-cell chronic lymphocytic leukemia.