A similar accumulation of CLL cells was observed in all compartments in TCL1-Tg and TCL1-Tg APRIL-/- mice, with an exception in older TCL1-Tg APRIL-/- mice having fewer CLL cells in the blood at 10 months but more in the bone marrow at age 8-9 months (Figure 3A). The gene discussed is TNFSF13; the disease is B-cell chronic lymphocytic leukemia.