Therefore, this study aimed to analyze the correlation of the PSMA volumetric parameters (PSMA-TVp) and prostate total lesion PSMA (TL-PSMAp) in newly diagnosed PCa lesions using 18F-PSMA-1007 PET/CT imaging with clinical and pathological characteristics in comparison with SUVmax to determine the clinical value of volumetric parameters in the metastatic state of PCa. This evidence concerns the gene FOLH1 and posterior cortical atrophy.