BCR and B-cell chronic lymphocytic leukemia: However, in another phase II study later on with R/R CLL patients that received prior treatment with a BCR inhibitor, the ORR of entospletinib was only 32.7% (95% CI, 21.7-45.3%) with a PFS of 5.6 months (95% CI, 3.7-8.3) (Table 1) (78).