Lately, it was reported that CRISPR-Cas9 induced disruption of CXCR4 signaling significantly affects not only the migration and homing of CLL cells with RT, but also reduces cell growth in murine and patient-derived xenograft models and impairs BCR-mediated signaling (186). The gene discussed is CXCR4; the disease is B-cell chronic lymphocytic leukemia.