SERPINE2 and cancer: Moreover, serpin E2 is overexpressed in many cancers, including liver cancer (Hou et al., 2019; Zhang X. et al., 2020), non-small cell lung cancer (Dokuni et al., 2020; Zhang et al., 2022), breast cancer (Tang et al., 2019), osteosarcoma (Mao and Wang, 2016), bladder cancer (Li F. et al., 2020), and melanoma (Perego et al., 2018), among others; this overexpression can promote tumor proliferation, metastasis, and colony formation (Liu et al., 2019), which are characteristics related to the tumor microenvironment (TME) (Bejarano et al., 2021).