AIF1 and Gliosis: The percent area occupied by Iba1-immunopositive cells and GFAP-immunopositive cells in the hippocampus (1.66 ± 0.133 vs. 2.92 ± 0.198, p = 0.0005; 3.69 ± 0.111 vs. 7.56 ± 0.283, p = 0.0007, respectively, Figures 3D,E) and cerebral cortex (2.41 ± 0.160 vs. 3.99 ± 0.151, p = 0.0003; 4.63 ± 0.391 vs. 6.78 ± 0.280, p = 0.0012, respectively, Figures 4D,E) was significantly greater in the AppNL-G-F-TE group than in the control group, indicating gliosis in AppNL-G-F mice associated with early tooth loss.