MAPT and Alzheimer disease: The main pathologic hallmarks of AD include the accumulation of extracellular amyloid-β (Aβ) plaques and aggregates of intracellular phosphorylated tau-laden neurofibrillary tangles, neuroinflammation, and synaptic and neuronal losses (Selkoe, 2001; Wirths and Bayer, 2012).