IL6 and cancer: It has been reported that IL-6 (−634G>C) and IL-6R (48892A>C) genetic polymorphisms are associated with the risk or prognosis in patients with some cancers (DeMichele et al., 2009; Motoyama et al., 2012; Stephens et al., 2012; Kibe et al., 2014; Ruzzo et al., 2014; Zhang et al., 2017; Gu et al., 2023).