We found diagnostic and predictive biomarkers of type 2 DCM consisting of OXCT1, CACNA2D2, BCL7B, EGLN3, GABARAP, and ACADSB, which may reduce the difficulty of early prediction of diabetic cardiomyopathy, and lay a foundation for prospective research. Here, CACNA2D2 is linked to diabetic cardiomyopathy.