On the one hand this is in contrast to findings showing that Sirt1 expression was reduced in human atherosclerotic plaques and vascular smooth muscle cells (VSMCs) but on the other hand in the same publication no reduced Sirt1 expression could be detected in aortas of ApoE deficient mice, which we then also saw in our study in the PCSK9DY/WD based atherosclerosis mouse model (57). This evidence concerns the gene APOE and atherosclerosis.