PGRMC1 and ischemic stroke: Based on findings that the miRNA let-7i downregulates expression of Pgrmc1 in peripheral tissue (159), and that the antagomir to let-7f, a sister miRNA to let7i, is neuroprotective in models of ischemic stroke (164), we hypothesized that administration of an antagomir to let-7i, when combined with progesterone, could promote enhanced BDNF release and provide protection in experimental models of ischemic stroke (118).