Myo-inositol is a new drug that is gaining importance in the treatment of PCOS. Our study used a comprehensive approach to show that treatment with myo-inositol resulted in the regularization of menses and improvement in endocrinological (significantly lower LH and LH/FSH) and metabolic parameters (significantly lower fasting insulin and HOMA-IR). This evidence concerns the gene INS and polycystic ovary syndrome.