The corresponding 16 gene representatives are listed in Table 2, among which a total of 11 genes, including FGF1, S100A1, DAD1, RPS4Y1, PJA2, TCIRG1, PTPN14, PAK1, KLKB1, OR1G1, and PITRM1, were shown also to be closely related to Alzheimer's disease or neurological diseases by other research. The gene discussed is PAK1; the disease is early-onset autosomal dominant Alzheimer disease.