Patients with NT1, previously reported as narcolepsy with cataplexy, have low levels of hypocretin-1 (HCRT-1) in the CSF, whereas patients with NT2 do not exhibit cataplexy and display normal levels of HCRT-1; however, few patients with narcolepsy and cataplexy with physiological levels of HCRT-1 on CSF have been reported [1]. The gene discussed is HCRT; the disease is narcolepsy.