CXCR4 and glioma: SOX10 is a transcription factor implicated in oligodendroglial differentiation and is overexpressed and hypomethylated in histone-mutant glioma, with a key functional role in viability, migration, and invasion of DIPG cells.34,35 Another gene of interest that was identified among the top genes by promoter JSD was CXCR4.