Previous studies have demonstrated that HOXA cluster genes are aberrantly expressed in DIPG, and that MEOX2 and numerous HOXA cluster genes are among the transcription factors correlated with patient survival in glioma.38,40 In summary we show that DNA hypomethylating drug treatment can reverse focal epigenetic dysregulation that is characteristic of DIPG. Here, MEOX2 is linked to central nervous system cancer.