SOX10 is a transcription factor implicated in oligodendroglial differentiation and is overexpressed and hypomethylated in histone-mutant glioma, with a key functional role in viability, migration, and invasion of DIPG cells.34,35 Another gene of interest that was identified among the top genes by promoter JSD was CXCR4. The gene discussed is CXCR4; the disease is central nervous system cancer.