The study cohort was divided into two groups: Group 1 consisted of 50 women with uncomplicated pregnancies, while Group 2 comprised 50 women experiencing symptoms indicative of threatened miscarriage.<h4>Results</h4>Notably, within Group 2, patients who eventually experienced miscarriage exhibited significantly elevated serum high-sensitivity CRP levels in comparison to those who maintained their pregnancies.<h4>Conclusions</h4>Threatened miscarriage cases demonstrated a substantial increase in serum high-sensitivity CRP levels compared to the control group. The gene discussed is CRP; the disease is spontaneous abortion.