Grounded in the understanding that osteosarcoma's genesis is intricately linked to osteoblasts [6, 7], it is worth noting that the nuclear factor κb ligand-receptor activator (RANKL), an osteoblast secretory product, has been classified within the Tumor Necrosis Factor (TNF) receptor ligand family [8-11]. Here, TNFSF11 is linked to osteosarcoma.