CD8A and hepatocellular carcinoma: According to a chronological analysis of CD8+ T cells performed with early‐stage recurrent hepatocellular carcinoma samples, the initiation of the differentiation phase depends mainly on lipid and lipoprotein metabolism, whereas the effector phase at later stages of development is primarily fueled by fatty acids, implying that early T‐cell differentiation is more closely related to the gene expression phenotype of previously activated CD45RO+ Tms.39, 51, 52