Continuous antigenic stimulation and the inflammatory response in the tumour immunosuppressive microenvironment can lead to metabolic reprogramming of CD8+ Tms cells, which results in their differentiation into end‐stage memory cells; these cells exhibit high cytotoxicity but low proliferative capacity, and Tcms and Tscms undergo apoptosis to promote stem cell differentiation.59 Here, CD8A is linked to neoplasm.