In an early study of recurrent hepatocellular carcinoma, CD8+CCR6+ T cells, which act as initiators of redifferentiation, differentiated into intermediate cell types in a cytotoxic state with high expression of classical cytotoxic genes (GZMK, GZMH, GZMA) and low expression of exhaustion phenotype‐related genes (PDCD1, CLTA4, HAVCR2). The gene discussed is CD8A; the disease is hepatocellular carcinoma.