In addition, chromatin immunoprecipitation sequencing revealed that the promotion of glutamine conversion to α‐KG positively regulates Foxp3 methylation by increasing the 2‐HG level, which increases the Th17 cell differentiation rate and disrupts the negative regulation of tumour immune function by Foxp3+CD4+ Tregs.120, 121. The gene discussed is FOXP3; the disease is neoplasm.