Infiltrating CD8+ Tms within tumour tissues upregulate phosphoenolpyruvate 1 (Pck1) expression, enhance gluconeogenesis or activate the glycogenolysis pathway, activate the pentose phosphate pathway to produce glucose‐6‐phosphate for consumption in NADPH synthesis, and indirectly generate reduced glutathione to defend Trms against oxidative stress.93 The gene discussed is CD8A; the disease is neoplasm.