To investigate the impact of SP140 and TRIM22 expression on the functional status of glioma, we proceeded with single‐cell analysis using the primary glioma dataset (GSE57872) and employed CancerSEA (http://biocc.hrbmu.edu.cn/CancerSEA/home.jsp) for the analysis and visualization of the results. The gene discussed is TRIM22; the disease is central nervous system cancer.