Memory B cells, activated myeloid dendritic cells, M0 and M1 macrophages, plasma cells, and CD4 + memory activated T cells showed significant increases in the lung cancer group, while resting myeloid dendritic cells, eosinophils, activated mast cells, Monocytes, neutrophils, and CD8 + T cells exhibited significant decreases. The gene discussed is CD8A; the disease is lung cancer.