The results are overall consistent with the knowledge of cancer metabolism: for example, increased intracellular concentration of L-leucine associated with KRAS mutation in amino acid metabolism [39], and generation of D-2-hydroxyglutarate (carbohydrate metabolism) [19] and altered cholesterol homeostasis (lipid metabolism) [40] as a result of the IDH1 mutation. The gene discussed is IDH1; the disease is cancer.