Greater similarities were observed between Recon 2M.2 and Human1 for the RCC samples as the target metabolites with AUC values greater than 0.7 were commonly associated with IGF1R, NOTCH, PBRM1, SETD2, or VHL (Figs. 3h and 6h). This evidence concerns the gene PBRM1 and renal cell carcinoma.