In glioblastoma cells having the IDH1 mutant, pyruvate [58], glutamate [58], lactate [59], and choline [60] were also found to show different intracellular concentrations, or biosynthetic reactions for these metabolites were shown to have different activities, compared to the counterpart cells having the wild-type IDH1 (Fig. 5a). The gene discussed is IDH1; the disease is glioblastoma.