This paper retrieval was implemented twice, once with an additional keyword of “glioma” and the second round with “cancer.” The paper retrieval showed that the previous studies on gliomas appeared to be largely focused on four target genes (CIC, EGFR, IDH1, and TP53), all cancer driver genes [45], among the 13 target genes (Fig. 5b). This evidence concerns the gene IDH1 and central nervous system cancer.