In the present study, we showed an inverse association between LAV-BPIFB4 homozygous genotype and markers related to inflammation, a remarkably benefit of LAV-BPIFB4 supplementation on colonic biopsies derived from IBD patients and a LAV-BPIFB4 favourable effect on the butyrate activity (Fig. 8). The gene discussed is BPIFB4; the disease is inflammatory bowel disease.