For instance, NF-κB is involved in proliferative signaling in various lymphoid malignancies, and although further investigation is needed, gene expression profiling studies have shown increased expression of NF-κB-related genes in PTCL, and the induction of apoptosis in PTCL cells by NF-κB inhibitors supports the notion that this pathway plays a significant role in PTCL. The gene discussed is NFKB1; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.