Male patients with AECOPD had higher level of inflammation indices, such as higher white blood cells and C-reactive protein (CRP), but female patients were more likely to have CT manifestations that indicate pulmonary infection, such as atelectasis/consolidation, pleural effusion, bronchiectasis, etc. Eosinophils have become an important biomarker in the management of stable COPD and AECOPD [33, 34]. The gene discussed is CRP; the disease is Pleural effusion.