Data from immunofluorescence staining of anti-CD161 antibody in MOC2 and TC-1 tumor tissues confirmed the results from flow cytometry (Fig. 5G), supporting the notion that IL6 signaling contributes more to NK cell tumor infiltration and antitumor efficacy in HPV − HNSCC, and blocking this signaling facilitates tumor infiltration and proliferation of NK cells. Here, KLRB1 is linked to head and neck squamous cell carcinoma.