CCR2 and head and neck squamous cell carcinoma: Coupled with rigorous scRNA-seq analysis and experimental validation in highly clinically relevant animal models, our work has demonstrated that simultaneous blockade of IL6 and CCR2 is a potential approach to enhance the antitumor activity of NK cells in HPV − HNSCC, providing a scientific rationale for the development of more effective immunotherapy-based treatments for this disease subset.