In the present study, we found that treatment of COPD BC with 1μM quercetin for 3 days significantly increases the expression of developmental genes including HOXB2, ELF3, ELF5, GRHL1, GRHL2, and WNT5A in these cells and this was associated with improved polarization and differentiation. Here, GRHL2 is linked to chronic obstructive pulmonary disease.