CDKN2A and neoplasm: Due to the critical role of senescent stromal cells in tumor progression, several studies have reported that the use of either genetic approaches to clear p16INK4A-expressing cells or small molecule inhibitors (e.g., ABT-263) that selectively induce apoptosis of senescent stromal cells can significantly improve the efficacy of chemotherapy and lead to an increased healthy lifespan in tumor-bearing mice [10, 11].