CD276 and urinary bladder cancer: Data from five studies [32, 33, 37–39], including 1292 patients with bladder cancer and 420 nontumor tissue samples, demonstrated that B7-H3 expression was significantly higher in bladder cancer compared to nontumor tissue samples (OR = 4.45, 95% CI = 1.47–13.49, P = 0.008) (Fig. 2).