The results of the meta-analysis indicated significant associations between high B7-H3 expression and age (Fig. 3A), higher tumor stage (Ta-2 vs. T3-4) (Fig. 4A), advanced tumor stage of muscle-invasive bladder cancer (MIBC) (T2 vs. T3-4) (Fig. 4D), and recurrence (Fig. 3E). This evidence concerns the gene CD276 and neoplasm.