To construct a risk model based on mTOR/Hippo genes for predicting the prognosis of HCC patients, we identified a risk model consisting of 12 genes, including CD44, FLT3, MAP4K1, LIN28B, WNT8A, GPC1, EIF4E, KIT, CYCS, PPARGC1A, BNIP3 and RRAGD (Figs. 2A–B and S1A–B). This evidence concerns the gene CYCS and hepatocellular carcinoma.