CD248 has also been shown to have a role in promoting inflammation—in autoimmune diseases, CD248 is known to be upregulated on fibroblasts and pericytes of synovial tissue and mesenchymal cells of the skin as KO of CD248 cytoplasmic domain showed significant reductions in inflammatory cytokines, synovitis, and arthritis in murine models. The gene discussed is CD248; the disease is arthritic joint disease.