IL6 and Hepatitis: Similarly, He et al. [49] noticed a marked increase in the hepatic protein expression levels of NF-κB P65 (sixfold) and mRNA expression levels of IL-6 and IL-1β, the master regulators of fibrosis by about 2.6 and 6.6-fold, respectively, in CdCl2-treated mice versus normal untreated animals, which suggest suffering of liver inflammation.