Another notable large effect-size hit which was validated across all 3 proteomics platforms in CSF and urine in both baseline de novo PD and non-manifesting carriers was Dipeptidyl Peptidase 7 (DPP7), also known as Dipeptidyl Peptidase 2 (DPP2), a serine protease of unknown function. Here, DPP7 is linked to Parkinson disease.