But Ma et al, have challenged the proposed harmful role of AIM2 in MS and EAE as they found the Aim2-/- mouse presented strengthened microglial activation and peripheral immune cell infiltration, enhanced neuroinflammation, and worse pathological outcome, which is surprisingly due to alleviation of the cGAS-STING pathway (Ma et al, 2021). This evidence concerns the gene STING1 and myeloid sarcoma.