TARDBP and amyotrophic lateral sclerosis: Mutant TDP-43 in ALS accumulates in cells and is able to shuttle between mitochondria and cytoplasm: it can enter mitochondria via TOM20 in the outer membrane and TIM22 in the inner membrane, then open an mPTP-mediated tunnel to release mtDNA (Paolicelli et al, 2017; Yu et al, 2020).