In addition to immune cells, cGAS is reported to be expressed in astrocytes in vitro (Jeffries and Marriott, 2017) and may have a central role in the rare genetic disease Aicardi-Goutières syndrome(AGS), which is characterized by abnormal IFN-I overproduction (Giordano et al, 2022). Here, CGAS is linked to Aicardi-Goutieres syndrome.