IFNAR1 and Parkinson disease: Main et al, found that the blockade of IFNAR1 rescues neuroinflammation and dopaminergic neuron loss in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD-like mice (Main et al, 2016), and offer a possible link between IFN-I toxicity and mitochondrial dysfunction since they find IFNAR1 blockade protects neuron from rotenone, a classical complex 1 inhibitor in another study (Main et al, 2017).