CGAS and Cognitive impairment: Gulen et al found that mitochondria-derived DNA leakage in microglia from the aged brain could stimulate the cGAS-STING pathway, triggering expression of the IFN-I gene, leading to microglia activation, neuroinflammation and accelerating cognitive impairment, which can be restored by either pharmaceutical STING blockage using H-151 or genetic sting1 deletion in mouse (Gulen et al, 2023).