IL1B and Alzheimer disease: They also highlighted the morphology and gene expression changes of microglia in response to IFN-I, including extended process, inflated soma, enhancement of phagocytosis, and upregulation of pro-inflammatory genes (Cd68, Clec7a, Il1b, Il-6, and Tnf), indicating that IFN-I-induced alteration of microglia is universal and profound in AD (Moore et al, 2020; Roy et al, 2022; Roy et al, 2020).