However, it was shown to be effective in reversing neuronal toxicity from senescent BV2 cells by TNF-alpha antibody instead of IFNAR1 antibody, which challenges results from another study that genetic IFNAR1 deletion can attenuate senescence-derived microglial phenotype changes, neuronal loss, and neurodegenerative disease progression (Nazmi et al, 2019). Here, IFNAR1 is linked to neurodegenerative disease.