Besides inflammasome formation, AIM2 has been found to directly bind with DNA-PK to inhibit the activation of protein kinase B (PKB, also known as AKT), resulting in colon tumor growth suppression and microglia-mediated neuroinflammation restriction in two individual studies (Ma et al, 2021; Wilson et al, 2015). This evidence concerns the gene AKT1 and colonic neoplasm.