We also noticed that the levels of lipid markers and LSRscore were not affected by age (Appendix Fig. S7), smoking status, EGFR mutations, COPD (chronic obstructive pulmonary disease) and bronchiectasis (Appendix Fig. S8), confirming the stability of lipid marker and LSRscore classification. The gene discussed is EGFR; the disease is chronic obstructive pulmonary disease.