Although NT-proBNP is known to be influenced by renal function, and we observed worse renal function in the 2022 patient cohort, our findings demonstrate that the NT-proBNP ratio emerged as a potential factor compared to NT-proBNP/eGFR (AUC = 0.757, P < 0.001) for predicting in-hospital mortality in COVID-19 patients. The gene discussed is NPPB; the disease is COVID-19.