However, the role of ATGL-induced lipolysis in the regulation of endothelial function during postprandial hyperlipidemia and the mechanistic insight linking LDs formation with the activation of endogenous ATGL-cPLA2-AA-PGI2 pathway evidenced in the present work shed a novel light into the pathophysiological relevance of the formation and the vasoprotective role of vascular LDs. Here, PLA2G4A is linked to hyperlipidemia.