In the presence of each inhibitor administered alone, atglistatin (200 μmol/kg), administered together with olive oil, AACOCF3 (cPLA2 inhibitor, 10 mg/kg) or RO3244794 (selective PGI2 receptor antagonist, 50 mg/kg) administered 3 h after olive oil gavage, Ach-induced response was further deteriorated (Fig. 8A, B) suggesting that postprandial endothelial dysfunction was aggravated by ATGL, cPLA2 or IP receptor blockade in vivo. The gene discussed is PTGIR; the disease is endothelial dysfunction.