LGALS3 and neoplasm: Similarly, the mice bearing “wild-type” tumors exhibited no brain response in all the signature regions when treated with the Gal3 small-molecule inhibitor GB1107 (Supplementary information, Fig. S7a).27 Further, this pharmacologic inhibition of the Gal3 signal led to the strong suppression of tumor growth (Supplementary information, Fig. S7b).