In the high UCHL1 subgroup, fructose and mannose metabolism, galactose metabolism, hippo signaling pathway-multiple species and pentose phosphate pathway were significantly enriched whereas systemic lupus erythematosus, ABC transporters allograft rejection, Intestinal immune network for IgA production, Graft-versus-host disease were significantly enriched in the low UCHL1 subgroup (Fig. 8D). This evidence concerns the gene ABCG2 and systemic lupus erythematosus.