TGFB1 and multiminicore myopathy: M Yamamoto et al. first pointed out that TGF-β1 is a potent enhancer of elastin expression in arterial SMC, and the expression of this gene is significantly increased in MMD patients49, while some other studies in recent years have pointed out that the polymorphism of TGF-β It is closely related to the progression of MMD in European races50,51, but research by Xiaomeng Wang et al. suggests that this polymorphism has no clear relationship with MMD in Chinese populations52.