To select primary PDAC models, we classified our proprietary PDAC-PDX panel into known prognostic molecular subtypes, namely classical tumor vs. basal-like tumor10, and Myc-signal low vs. Myc-signal high11, by using RNA sequencing (RNA-seq) data on PDX tumors (Supplementary Fig. 1a). The gene discussed is MYC; the disease is neoplasm.